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A co-lyophilised blend reduces handling steps and the number of reconstitution events, which is convenient when a research protocol consistently uses the two peptides at a 1:1 mass ratio

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Details of equivalent of protected amino acid/fragment, reagent and solvent were as below: On completion of solid phase synthesis the resin was removed from the assembly and dried to get Boc- Tyr(tBu) 1 - Aib - Glu(OtBu) - Gly - Thr(tBu) 5 - Phe - Thr(tBu) - Ser(tBu) - Asp(OtBu) - Tyr(tBu) 10 - Ser(tBu)- He - Aib - Leu - Asp(OtBu) 15 - Lys(Boc) - lie - Ala - Gln(Trt) - Lys 20 (Side chain) - Ala - Phe - Vai - Gln(Trt) - Trp 25 - Leu - He - Ala - Gly - Gly 30 - Pro - Ser(tBu) - Ser(tBu) - Gly - Ala35 - Pro - Pro - Pro - Ser(tBu) 39 -Rink Resin -32g (Boc-(01-39)-Rink Resin)

Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia