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According to Zhang et al., sevoflurane and isoflurane might induce neuroinflammation and cognitive impairment by increasing the level of interleukin-6 (IL-6) via nuclear factor-kappa B (NF-B) signaling, which is associated with M1 activation (Zhang et al., 2013)

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In these cases, oral administration is ineffective, making injections the only reliable route to replenish stores

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An early uncontrolled study found that 10 out of 16 HIV-positive subjects with painful neuropathy reported improvement after three weeks of intravenous or intramuscular ALCAR treatment (79)