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le Roux 2 , Adie Viljoen 1 Endocrinology and Metabolism 2024;39(1):12-22

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As mechanistic insights into iron homeostasis, lipid peroxidation, and immunometabolic interactions continue to deepen, alongside progress in drug delivery, gene editing, and regenerative medicine, therapies targeting ferroptosis may represent a promising new paradigm in OA management, ultimately enhancing joint function and overall quality of life for affected individuals

430 In their normal resting state, Ras proteins remain in an inactive GDP-bound conformation

Therefore, a biopsy of the heart muscles, called an endomyocardial biopsy, may be performed to test the levels right from the source