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based on rodent studies

Steroids 59(2):121126 Krueger J, Bowcock A (2005) Psoriasis pathophysiology: current concepts of pathogenesis

PLoS Biol (2010) 8(6):e1000412.10.1371/journal.pbio.1000412 42 HoSNHuntHDHortonRMPullenJKPeaseLR

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Adems, la actividad de la metilentetrahidrofolato reductasa aumenta, lo que determina que los folatos intracelulares se dirijan a los depsitos de metiltetrahidrofolato, el cual es atrapado a falta de sustrato