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But the details matter, and the details are where most providers fall short

Use of DPP-4 inhibitors, GLP-1 receptor agonists, and SGLT-2 inhibitors is on the rise owing, at least in part, to their glycemic benefits, lack of weight gain, and complementary mechanisms of action when used in combination with metformin or other antihyperglycemic medication classes

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Other mechanisms presumably involve active tubular secretion via renal transporters (Organic Anion Transporter-3 (OAT3) or P-glycoprotein (P-gp))