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The sequence (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) was isolated by Croatian researcher Predrag Sikiric and his colleagues in the 1990s, who discovered that this fragment retained the protective biological activity of the parent gastric compound

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Garcia, M.R., and Wilson, K.L

The mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving cerebral blood flow, and modulation of dopamine and serotonin systems