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DNA demethylation DNA demethylation involves the removal of methyl groups from cytosine residues in DNA, typically mediated by demethylases such as TET1, TET2, and TET3

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In fact, OLE treatment enhanced insulin-stimulated glucose uptake, the translocation of GLUT4 at the plasma membrane, and the levels of Akt substrate of 160 kDa (AS160) phosphorylation

We proposed that by exploiting the abundant amount of reactive iron(II) in DTP cancer cells 6,7,8 , such a bifunctional molecule would form an active catalyst in the cell to promote the oxidative degradation of lysosomal membrane lipids and ultimately trigger ferroptosis