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The relevance of impaired selenium metabolism to the onset of KBD was further validated using a mouse genetic deletion model

The low-dose daily approach starts at 200 mcg per day and steps up to about 1 mg per day

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4-7 During midlife, the decreased amount of estrogen in a womans musculoskeletal system results in loss of lean muscle mass, loss of bone density, increased risk of fracture, increased injury to tendons and ligaments, adhesive capsulitis, cartilage matrix fragility leading to osteoarthritis, musculoskeletal pain, and metabolic dysfunction