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The retatrutide group showed an average weight loss of 8.96 kg (or 10% of their body weight)

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Butyrate and propionate both have been associated with the prevention of various allergic diseases and, consequently, high faecal levels of these fatty acids in early life have been associated with a decreased risk of developing atopy (207209)

The CYP3A4 induction and inhibition assays also highlight the potential of iHLOs for dynamic pharmacological testing, a key aspect of drug safety evaluations 35

The SI of MFI of ROS-producing PMN ( Supplementary Table 3 ) remained at the same level for 4 h after the immune challenge and showed the significant highest capacity at 9 h pi , followed by a reduction to baseline values until the end of the trial