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Ethics declarations Ethics approval and consent to participate All animal experiments were conducted after approval from the Institutional Animal Care and Use Committee of the Tongji Medical College, Huazhong University of Science and Technology, and all procedures were in compliance with the relevant guidelines and regulations of the Chinese Council on Animal Care

Manufactured in a cGMP-certified facility, each batch is verified with CryoTEM for liposome presence and undergoes third-party testing to ensure purity and potency

Translation is limited at present by on-target injury in normal tissues and by off-target pathway perturbations, necessitating solutions that separate lesion efficacy from systemic risk

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12 weeks 84 syringes 1 per day