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Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro3) GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice

In these STEP trials, most participants experienced mild to moderate symptoms, with the incidence of severe side effects being 9.8% in the semaglutide treatment group and 6.4% in the placebo group

Constipation is the most common overlap

Smoking rates also drop among GLP-1 users as nicotine cravings decline during treatment

For example, in Canada, attention is already shifting towards newer entrants like tirzepatide (Mounjaro/Zepbound), which has demonstrated superior efficacy in weight loss in the head-to-head SURMOUNT-5 trial iii and is gaining momentum