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Oftentimes, patients with chronic pain who are prescribed opioids develop tolerance to them, along with psychological, behavioral, and emotional issues, including anxiousness and depression related to under or overprescribing opioids

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With more patients stepping forward, the litigation is expected to expand, potentially leading to changes in how these medications are labeled and marketed

Blind cage coding and automated video analysis (EthoVision, TopScan) are recommended Too low n : prior power analysis, n 8 minimum for rodent behavioural tests No positive control : without memantine, donepezil or scopolamine depending on the paradigm, impossible to judge if the model is functional No dose-response : a single tested dose is insufficient to conclude

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