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In pediatric patients who have growth hormone deficiency (GHD), treatment with somatropin stimulates linear growthand normalizes concentrations of Insulin-like Growth Factor -I (IGF-I).In adults with GHD, treatment with somatropin results in reduced fat mass, increased lean body mass, metabolic alterations that include beneficial changes in lipid metabolism, and normalization of IGF-I concentrations
doi: 10.1016/j.tiv.2017.04.020
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