Research shows that taking 3 g per day for six weeks can saturate keratinocytes in the skin, but taking more does not increase levels and may cause diarrhea
Risk of Hypoglycaemia The likelihood of low blood sugar is assessed, particularly if the patient is already on insulin or sulfonylureas
In PD, a ketogenic diet trial (very high fat, low carbohydrate) is underway, hypothesizing shifts in the microbiome/metabolome (elevated ketones and possibly Akkermansia ) with potential motor benefits [236]
Rather than completing the full discontinuation, your PlexusDx clinician may recommend holding at a lower maintenance dose (0.5-1.0 mg weekly) indefinitely, similar to how insulin-dependent patients manage diabetes long-term
Roehrborn C, Siami P, Barkin J, et al