( The effect of LC on BP has shown mixed results in various studies
This may be related to curcumins effect on GLP-1
This is a known design problem in GPCR pharmacology, with a body of literature around "biased agonism" molecules that engage the receptor at the cell surface but minimize the intracellular machinery that pulls the receptor into endosomes
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Additionally, TF triggers intracellular signaling cascades via protease-activated receptor 2 (PAR-2), promoting the production of proangiogenic factors, cytokines, and adhesion molecules, thereby fueling tumor growth, angiogenesis, and metastasis 144