14, 629635.10.1046/j.0956-7976.2003.psci_1476.x 15 BenjaminA
It is engineered to bind with high affinity to three distinct receptor sites, creating a metabolic environment conducive to rapid fat oxidation and glycemic control
The most realistic approach for most people: use the keto plus GLP-1 combination during the active weight loss phase (typically 6 to 18 months), then transition to either maintained keto as a GLP-1 exit strategy, continued GLP-1 at a maintenance dose with a more moderate low-carb diet, or a gradual return to a protein-prioritized diet that may include more carbohydrates than strict keto while maintaining the metabolic awareness and habits built during the keto phase
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These receptor proteins are characterized by the presence of LIR motifs for the interaction with ATG8 family proteins such as LC3 on the surface of phagophores, and many have ubiquitin-binding domains capable of recognizing ubiquitinated cargo, thus establishing a bridge between the cargo and the autophagic machinery (40, 92, 93)
