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During the early stage of repair, inflammatory activation helps clear pathogens and damaged tissue, facilitating the transition from the inflammatory phase to the proliferative phase, thereby promoting the healing process of DFU wounds [38, 41, 42]

Adipocyte (Fat Cell) Function Studies : Investigating changes in fat breakdown (lipolysis) and fat storage (lipogenesis) in isolated adipose tissue or cultured fat cells, including measurement of glycerol and free fatty acid release as metabolic markers

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Many HR genes are S phase regulated, but we saw no differences in S phase in IDH1-inhibited or TMLHE-knockdown cells (Extended Data Fig

Additionally, there was a notable increase in tumor-penetrating CD3 + , CD4 + , and CD8 + T cells in mice undergoing the combined therapy, indicating that jointly inhibiting MET and PD-L1 significantly boosts the mice's ability to fight tumors [134]