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Current clinical trials and future studies should take into account gender-dependent factors, receptor polymorphism, and the selectivity of brain regions in order to optimize the translational potential of this strategy [114]

Effect of weight loss on cardiometabolic risk: observational analysis of two randomised controlled trials of community weight-loss programmes

Sin embargo, algunos pacientes reportan mayor vitalidad debido a mejoras indirectas como la estabilizacin de los niveles de azcar en sangre y cambios en la salud metablica

Additionally, those with wet AMD were not included

Potential direct benefits suggested by preclinical research include reduction of neuroinflammation, enhancement of neuronal insulin signaling, promotion of synaptic plasticity, and possible reduction in pathological protein accumulation