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What's next for GLP-1 innovation: A primer on the race reshaping pharma and chronic disease care Brandon Aylward Oct 16, 2025 10 min read Few categories in modern medicine have captured the imagination of patients, physicians, and investors as quickly as GLP-1 receptor agonists (GLP-1s)

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Safety profile: Oral semaglutide has a safety profile consistent with injectable forms, offering confidence in its long-term use

doi: 10.1016/j.jare.2022.11.003 50 DwibediCAxelssonASAbrahamssonBFaheyJWAsplundOHanssonOet al

But inadequate glycaemic control or intolerance to metformin may necessitate the use of GLP-1 agonist monotherapy like semaglutide