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Results: GHK-Cu alleviated weight loss, improved the disease activity index (DAI), reduced colonic edema and shortening, attenuated inflammatory damage, increased goblet cell numbers, suppressed inflammatory cytokines such as TNF-, IL-6, and IL-1, and promoted mucosal repair

Consistent with previous literature findings of weight loss in rodents following MC4R stimulation [47], mice treated with MT-II demonstrated significant weight loss over the 14-day treatment course

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A post hoc analysis of the phase IIb trial showed that tirzepatide was associated with a reduction in the level of high-sensitivity ICAM-1, CRP, and YKL-40 after 26 weeks of treatment in a dose-dependent manner [83, 103]

Behavioral support may include guidance for meal planning, setting realistic goals, and managing emotional eating