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Patients of different ethnicities living in both rural and urban settings were recruited

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A meta-analysis of 28 studies with 74,660 patients who had bioprosthetic valves and atrial fibrillation showed that DOACs were more effective in reducing the risks of bleeding, strokes, systemic embolism, and intracranial bleeding when compared to warfarin

The cumulative effect on heart rate and blood pressure has not been studied and could prove unpredictable