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-Cell-specific redox modulators, as the conjugated glucagon-like peptide-1 (MitoTEMPO) bv nanoparticles have achieved 80% -cell targeting efficiency in primates, preserving insulin secretion under glucotoxic conditions (Marques et al., 2024)

PubMed Central , Molecules , vol

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However, the expression of xCT can be induced in many types of cells in response to stress conditions such as oxidative stress and hyperoxia, which are likely mediated by transcriptional regulatory factors Nrf2 and ATF4 [51,52]

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