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The maximum dose of Ozempic is 2 mg once a week by subcutaneous injection to control blood sugar levels

Since hemoglobin is present in red blood cells and these cells have a limited life span of 120 days in the circulation, measurement of HbA 1c levels is a relatively accurate measure of the amount of glucose in the blood and the length of time the level has been elevated

Riis PT, Boer J, Prens EP, Saunte DML, Deckers IE, Emtestam L, et al

For this reason, it's contraindicated in patients with uncontrolled hypertension

A multidisciplinary expert consensus published in 2022 suggested pausing or reducing the dose of metformin therapy during initiation of a GLP-1 RA as an option to reduce GI side effects (Gorgojo-Martnez et al, 2022), although this is not widely practised in the UK