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PDE4 inhibitors, including CC-11050, CC-3052, and roflumilast, when combined with INH, have been shown to reduce the lung bacillary burden, lung pathology, and fibrosis, as well as the size and number of lung granulomas in M.tb -infected rabbits and in both acute and chronic TB mouse models [35, 108, 109]
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Hormonal changes, including pregnancy and menopause
Adaptive characteristics of innate immune responses in macrophages
At its heart, this therapy contains: Glutathione often called the "master antioxidant," this small but mighty protein is made up of three amino acids: cysteine, glycine, and glutamic acid
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