retatrutide ly3437943 phase 2 trial obesity nejm 2023 Eli Lilly's shows promising weight loss results in 3 Retatrutide just posted the biggest

In May 2024, as second study in the New England Journal of Medicine found that the risk of a primary heart or kidney event was 24% lower in the semaglutide group

This is likely due to the role of vitamin B12 in energy production and metabolism

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Clin Endocrinol (Oxf) (2014) 80(6):83442.10.1111/cen.12254 41 LeanMELeslieWSBarnesACBrosnahanNThomGMcCombieLet alPrimary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial

The analysis of transcripts from the wild-type and mutated alleles indicates that only the paternal allele is expressed in embryos, while the maternal allele is silent