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Combination in patients with Type 2 Diabetes Mellitus and Moderate Renal Impairment with Metformin alone, Sulfonylurea alone, Basal Insulin alone or Metformin in Combination with either Sulfonylurea or Basal Insulin In a 26-week, double-blind trial (Trial 5, NCT02827708), 324 adult patients with moderate renal impairment (eGFRCKD-EPI 30 to 59 mL/min/1.73 m2) were randomized to semaglutide tablets 14 mg orally once daily or placebo once daily

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Increase after 2-4 weeks if tolerated well and results warrant more