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Specifically, a recent phase 2a clinical trial found reductions in body weight and improvements in glucose control but the degree of the improvements seemed to be within the range of what is seen with long-acting GLP-1r agonists alone (3, 189)

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Genetics can also shape how much fat settles in the pectoral region

Attia G M, Almouteri M M, Alnakhli F T (August 31, 2023) Role of Metformin in Polycystic Ovary Syndrome (PCOS)-Related Infertility