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Addressing these gaps will require collaborative efforts among researchers, clinicians, and pharmaceutical companies to accelerate the translation of experimental therapies into clinical practice

For example, the 5, 10, and 15 mg doses of tirzepatide can be reached 4 weeks, 12 weeks, and 20 weeks, respectively, after treatment initiation, while the 1 mg semaglutide dose can be reached after 8 weeks [7, 8]

doi:10.1001/jama.2025.19615

Nature 632 , 383389 (2024)

Seek medical advice if you experience severe cognitive impairment affecting daily activities, sudden confusion with neurological symptoms, suspected hypoglycaemia (especially if taking insulin or sulphonylureas), signs of severe dehydration, or persistent symptoms despite lifestyle modifications