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Holst JJ, Windelov JA, Boer GA, Pedersen J, Svendsen B, Christensen M, Torekov S, Asmar M, Hartmann B, Nissen A

10.1038/s41419-023-06177-1 29 SuL.DongY.WangY.GuanB.LuY

Tomas A, Jones B, and Leech C

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Phase 3 monotherapy available Feature Expected GI burden Cagrilintide + Retatrutide Very high CagriSema (Cag + Sema) High Retatrutide Alone High Feature Dysesthesia risk Cagrilintide + Retatrutide Yes (retatrutide component) CagriSema (Cag + Sema) No Retatrutide Alone Yes Feature Injections per week Cagrilintide + Retatrutide 2 (separate) or 1 (pre-blend) CagriSema (Cag + Sema) 1 or 2 Retatrutide Alone 1 Feature Regulatory status Cagrilintide + Retatrutide Neither approved