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These approaches can be broadly categorized according to their target, including regulators of oxidative stress, lipid peroxidation, iron dysregulation, DAMP-mediated inflammation, profibrotic cytokines, and ECM remodeling ( Table 1 )

Tal et al., 2008, Tal et al., 2022

Nutritional ketosis for mild cognitive impairment in Parkinsons disease: a controlled pilot trial

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These data support an effect of IL-13 to decrease total and reduced GSH through high 15LO1, PEBP1, and GPX4 activity, which is partially compensated by (a) increased expression/activity of SLC7A11 to enhance new intracellular GSH production and (b) increased export of GSSG