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The findings aim to provide actionable insights for policymakers, clinicians, researchers and patients to advance DHT-driven, patient-centric approaches, ultimately improving patient outcomes and addressing the unmet medical needs of rare disease populations worldwide, ensuring they have equitable access to innovative treatments and improved healthcare

The pineal gland becomes less efficient with age, reducing melatonin output by up to 75 percent in older individuals

doi: 10.1016/S0140-6736(17)32520-5 130 KessenbrockKPlaksVWerbZ

doi: 10.4291/wjgp.v7.i2.211

Although most of these data were generated in regenerative settings rather than during steady-state aging, they support a model in which aging can reduce the MuSC pool through probabilistic loss or dysfunction of MuSCs (or labeled lineages) without implying deterministic, subset-specific collapse of heterogeneity (Fig