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Primary prevention of cardiovascular and heart failure events With SGLT2 inhibitors, GLP-1 receptor agonists, and their combination in type 2 diabetes

While losing weight is good for the heart, the medication itself can sometimes cause a slight increase in heart rate

In terms of energy metabolism reprogramming, the deletion of Pde3a and Pde3b inhibits mitochondrial oxidative phosphorylation and promotes glycolysis in PASMCs by downregulating the AMPK/CREB signal and upregulating PDK1/2/4

Caffeine boosts cortisol levels temporarily, which may contribute to weakened adrenals in the long term

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