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Chemoenzymatic synthesis of cysteine protease inhibitor To chemoenzymatically synthesize selective cathepsin L inhibitor CLIK-148, a large-scale 20-ml reaction in 50 mM sodium phosphate buffer (pH 8.0) containing 5 mM ()- t -ES, 2.5 mM l-Phe, 2.5 mM dimethylamine ( b28 ), 2.5 M Cp1B and 2.5 M Cp1D was carried out at 30 C for 16 h

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