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[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Chen J, Zhuang T, Chen J, Tian Y, Yi X, Ni Q, et al

Using data from mouse models where evidence for genetic variation in susceptibility to APAP DILI has also been obtained, polymorphisms in a set of candidate genes were genotyped in approximately 120 individuals for whom data on circulating ALT following APAP administration at 4 g per day for 7 days was available.67 Polymorphisms in CD44 (rs1467558), which codes for a protein involved in lymphocyte adhesion and activation, and in CAPN10 (rs3749166) which encodes a protease released following hepatocyte damage, were predictive for the extent of ALT elevation with borderline significant effects seen for those carrying rs1467558 or rs3749166

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Costell M, Mguez MP, OConnor JE, Grisola S