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New real-world evidence suggests that staying on GLP-1 therapy may be critical for sustaining cardiovascular protection, while even short interruptions could diminish long-term benefits in people with type 2 diabetes

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Stratification by cumulative dosage showed that higher cumulative dosage was associated with decreased rates of relapse

Users engaging in extended protocols should implement periodic monitoring through healthcare providers to ensure continued safety

The clinical information must document why the member cannot use Otezla, including why it is medically necessary that the member receive Otezla XR instead of Otezla