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Theranostics, 2 (8), 801-814

This theoretically preserves the cytosolic pool of NAD+ (Nicotinamide Adenine Dinucleotide), which is critical for sirtuin activation and mitochondrial oxidative phosphorylation

Nature Medicine , 28(5), 898-910

In further embodiments, the auris formulation or composition contains a viscosity enhancing agent or viscosity modulating agent sufficient to provide a viscosity of between about 10 and 1,000,000 centipoise, between about 100 and 1,000,000 centipoise, between about 500 and 1,000,000 centipoise, between about 750 and 1,000,000 centipoise

Either way, it is often caused by a deficiency in vitamin B12