The initial selection was done using the Students t -test and was based on a binary comparison (genes significantly different between LPS + BSO and LPS alone were selected)
REFERENCES United Nations Office on Drugs and Crime
"Most GLP-1 medications are peptides, which are large, water-soluble molecules
Moreover, given no heterogeneous treatment effects found by age, gender, or diabetes severity for GLP-1RAs versus insulin in our previous analyses [6] and limited study subjects with different patient characteristics in the present study, performing the cost-effectiveness analysis stratified by different patient demographic or clinical characteristics would be infeasible
This phenomenon is further illustrated by results from a randomized, open-label mechanistic trial in patients with T2DM, which demonstrated that lixisenatide, with a half-life of 2 4 hours, had a significantly greater effect than liraglutide in delaying in gastric emptying and curtailing postprandial glucose excursions following a standardized solid breakfast (156)
