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These experiments provided a rationale for later mouse studies but did not establish a human fat-loss effect

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As the disease affects all parts of the gastrointestinal tract, it does have some unique symptoms that differ from ulcerative colitis (like mouth ulcers) and is also more limited in terms of surgical options (i.e., you cant just remove the diseased areas and permanently cure it)

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Does systemic administration provide a holistic healing environment, while localized application gives a targeted boost