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To improve the prognosis of metastatic TNBC patients, antibodydrug conjugates (ADCs), such as sacituzumab govitecan, have been utilized to specifically deliver potent chemotherapy agents directly to cancer cells expressing targeted antigens, demonstrating promising efficacy [25]

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Expression of these AR circRNAs was upregulated during castration-resistant progression, with levels of AR circRNAs correlated strongly with those of the linear AR transcripts, indicating a transcriptional mechanism of regulation