Since then, several GLP-1s for obesity have been approved for new indications, such as secondary cardiovascular risk reduction (Wegovy), sleep apnea (Zepbound) and metabolic dysfunction-associated steatohepatitis, or MASH (Wegovy)
8 The authors attributed this adverse outcome to the large and rapid fall in hemoglobin A1c levels during the initial 16 weeks of the trial 9,10
Threats 12
When to call your provider Constipation is usually manageable, but see your provider if you experience fewer than three bowel movements per week for multiple consecutive weeks, severe abdominal pain or bloating, blood in your stool, or no relief from a combination of fiber, hydration, and OTC options
The semaglutide observational data suggests GLP-1 agonists may reduce smoking independent of their metabolic effects