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Literature Cited 1.Guerra-Shinohara EM, Morita OE, Peres S, Pagliusi RA, Sampaio Neto LF, DAlmeida V, Irazusta SP, Allen RH, Stabler SP

The same markers, factors, and cytokines necessary to drive cellular repair response can destroy cells and cause extensive damage

S-adenosylmethionine (SAMe), an amino acid derivative important in liver metabolism, and extracts from milk thistle ( Silybum marianum ), have been investigated (alone and in combination) in dogs for their liver-protecting properties and are currently used as part of treatment for a variety of liver diseases in dogs