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Microsomal GST1 (MGST1) and GSTP1-1, which are frequently overexpressed in cancer cells, contribute to DOX resistance

Mistake 1: Using acetate protocols for arginate dosing The improved bioavailability of the arginate form means that dose-for-dose, it delivers more active peptide to target tissues than the acetate form, especially via oral routes

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58 Interestingly, the expression of this enzyme does not fulfill an instantaneous snapshot of the blood toxicity, but an average value over a time span of about 2/3 months (corresponding to the mean life of the erythrocyte) as it is exclusively expressed during erythropoiesis

Enhanced Bioavailability : Delivers glutathione in a liposomal encapsulation to enhance absorption, safeguarding it from gastric degradation and facilitating its translocation across cellular barriers