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Activation of SSAT1/ALOX15 axis aggravates cerebral ischemia/reperfusion injury via triggering neuronal ferroptosis

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Normally, cells prefer to degrade glucose through aerobic glycolysis, which produces pyruvate that enters the mitochondria in the Tricarboxylic Acid Cycle (TCA) cycle, and subsequently in the electron chain transport, which led to the production of 32 ATP molecules from a single glucose fraction [8]