If levels of glutathione are already low due to on-going oxidative stress, the need for glutathione is even higher
Degraded peptides won't work
GS then catalyzes the second step, consuming another molecule of ATP to add glycine to -Glu-Cys, ultimately forming GSH
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In a 2013 study, 15 the GSH precursor N -acetyl cysteine (NAC) was administered as a single 60-min intravenous infusion (150 mg/kg) to individuals with PD and healthy controls