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This proportionality-based approach prioritizes early identification of constraint-sensitive drift rather than indiscriminate supplementation

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Co-infusion of GLP-1 and GCG has been shown to reduce glucagon-induced hyperglycemia, lower blood glucose levels, suppress food intake, and enhance energy expenditure in both diabetic obese mice and healthy human volunteers [78]

When glycemic control improves too quickly, patients with existing diabetic retinopathy may experience paradoxical worsening of their retinal disease