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In a murine model of renal cell carcinoma, upregulation of G6PD and subsequent increase in NADPH was found to inhibit ferroptosis whereas G6PD knockdown in human hepatocellular carcinoma cells increased positive regulators of ferroptosis 83,84,85

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Recent evidence suggests that the compartmentation of many enzymes associated with ROS processing or redox regulation is not as fixed as earlier concepts would suggest, and redox and other PTMs may facilitate re-localization of proteins to fulfil moonlighting functions (Foyer et al

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31 Nevertheless, -sheet-rich aggregates may cause difficulties with drug distribution due to their size and network-like character or may even trigger an immunogenic response