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In March 2026, Aardvark Therapeutics announced that the US FDA had placed a full clinical hold on its investigational new drug application for ARD-101 related to the Companys previously announced voluntary pause

The non-hormonal mechanism makes them safe to use alongside hormone therapy if desired

PT-141 is injected subcutaneously or taken intranasally

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Edema Lid retraction accompanied by lid lag Lid Lag Ion Channel Myopathy (if 2 mm, graded as moderate to severe) Exophthalmos/ proptosis Proptosis Retinoblastoma (if 3 mm, graded as moderate to severe) Diplopia Diplopia A visual symptom in which a single object is perceived by the visual cortex as two objects rather than one