Factors affecting efficacy Consistency: Regular, consistent use is crucial for optimal results
Neurosci Res 685 , e109e222 (2010)
Store under refrigeration at 36-46 degrees F / 2-8 degrees C unless your pharmacy label says otherwise
You should contact your GP if you experience : Unexplained weight gain , particularly affecting the face (moon face), neck (buffalo hump), and abdomen, with relatively thin arms and legs Persistent hypertension that is difficult to control with standard medications Easy bruising or thin, fragile skin that heals poorly Purple or red stretch marks (striae) on the abdomen, thighs, or breasts Muscle weakness , particularly affecting the shoulders and hips Mood changes including depression, anxiety, or irritability that persist despite usual management Irregular menstrual periods or reduced libido Recurrent infections or poor wound healing New-onset diabetes or worsening glycaemic control in established diabetes Seek urgent medical attention if you develop signs of adrenal crisis, which can occur in patients with adrenal insufficiency (often after withdrawal of long-term steroids)
Cycle Duration Study-dependent (acute to multiple weeks) Repeatable Single cycle Suggested Bloodwork (3 tests) CMP (Comprehensive Metabolic Panel) When: Baseline Why: Kidney and liver function baseline Urinalysis with protein When: Baseline Why: Assess proteinuria relevant to kidney disease applications Serum phosphorus and calcium When: Baseline Why: Klotho regulates phosphate and calcium homeostasis Key Considerations Preclinical only: no human clinical trials have been conducted with klotho peptides KP1 and KP6 are research reagents, not pharmaceutical products or supplements Full-length klotho protein cognitive effects use the much larger KL1 domain, not short KP1/KP6 peptides Unlock dosing protocols Free access to research-backed dosing information for all peptides
