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However, in rodent studies, some of these medications were associated with both benign and malignant thyroid C cell tumors

Tirzepatide is a dual GLP-1/GIP receptor agonist that targets two receptors, which clinical trials show produces greater average weight loss

Constipation is a recognised side effect, affecting up to 1 in 10 patients, primarily due to slowed gastric emptying and reduced gastrointestinal motility

However, the structure of the Fab 3F52/ECD complex revealed a broader overlap between the two ligands which extends outside the ECD binding site

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