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Retatrutide is not approved by the MHRA and cannot be legally prescribed in the UK outside of an authorised clinical trial

A microdosing strategy often requires a prescription for a compounded version from a licensed compounding pharmacy

Key mechanisms include the relief of hypothalamic-pituitary-ovarian (HPO) axis inhibition through weight loss and improved insulin sensitivity, alongside improved endometrial receptivity driven by increased SHBG and decreased free androgens (83, 167, 168)

Modern day therapeutics that are recombinant DNA based have minimized the issue of heterogeneity, however aggregates are still present to some extent in all drug formulations and need to be studied further